Table 1. Viral dissemination to peripheral organs.
WT mice were inoculated intracranially with reovirus T3D at 100 PFU/g at 2, 4, 6, 10, or 15 d of age. Viral loads in the brain, heart, liver, spleen, and intestine were determined by plaque assay at 4, 7, and 10 d p.i. n = 5–7 mice per condition. Numerals represent the number of mice with detectable titer in peripheral organs divided by the total number of mice assayed, and the resulting percentage on mice with detectable titer in peripheral organs in each group.
| Time post-inoculation (d) | ||||
|---|---|---|---|---|
| 4 | 7 | 10 | ||
| Age of inoculation (d) | 2 | 3/6 (50%) |
5/6 (83%) |
6/6 (100%) |
| 4 | 3/6 (50%) |
5/5 (100%) |
5/6 (83%) |
|
| 6 | 1/5 (20%) |
2/5 (40%) |
0/7 (0%) |
|
| 10 | 3/6 (50%) |
2/6 (33%) |
0/6 (0%) |
|
| 15 | 4/6 (67%) |
2/5 (40%) |
0/6 (0%) |
|