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CCI-induced thermal (top) and mechanical (bottom) hyperalgesia and antinociceptive effects of twice-daily 10 mg/kg 2-BFI in rats (n = 9 rats per group). Ordinates: top, paw withdrawal latency (s), bottom, paw withdrawal threshold (g). Abscissas: days after CCI surgery. *** P < 0.0001 main effect of CCI surgery or 2-BFI.
