Figure 4. Effect of glycyrrhizin on rrRSV infection in 16HBE cells.
(A) Representative pictures rrRSV-infected 16HBE and non-infected controls treated with the HMGB1 antagonist glycyrrhizin (50 or 100 μM) or vehicle. The density of cells exhibiting red fluorescence produced by active viral replication was significantly reduced by glycyrrhizin in a dose-dependent fashion. (B) Bar graph showing the number of rrRSV-positive cell in each group. Data are expressed as mean ± SEM. ***P<0.001 compared to RSV group. All experiments were repeated at least three times.