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. Author manuscript; available in PMC: 2018 Aug 21.
Published in final edited form as: Pediatr Res. 2018 Feb 21;83(5):1049–1056. doi: 10.1038/pr.2018.6

Figure 5. Effect of glycyrrhizin on rrRSV infection in human primary cells.

Figure 5

(A) Fluorescent microscopy of human primary cells treated with the HMGB1 antagonist glycyrrhizin (50 μM or 100 μM). (B) The number of cells exhibiting the red fluorescence produced by active viral replication was significantly reduced by glycyrrhizin in a dose-dependent fashion. (C) Consistently, qPCR measured a significant reduction in RSV F RNA levels in response to treatment with glycyrrhizin. (D) Western blot analysis with corresponding densitometry demonstrated downregulation of HMGB1 protein expression upon glycyrrhizin treatment. Data are expressed as mean ± SEM. ***P<0.001 compared to RSV group. All experiments were repeated at least three times.