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. Author manuscript; available in PMC: 2019 Jul 1.
Published in final edited form as: Biochem Pharmacol. 2018 Jan 31;153:205–216. doi: 10.1016/j.bcp.2018.01.044

Figure 2.

Figure 2

Role of BChE in ghrelin metabolism and signaling in the brain. Top panel: Main organs, brain regions, and pathways involved in fear response. Red arrows indicate blood-borne delivery. Bottom panel: Key interacting centers: parvo-ventricular nucleus of the hypothalamus (PVN); dorsomedial and ventromedial prefrontal cortex (PFC); dorsal raphé nucleus (DRN); adrenal cortex; and pituitary gland. Arrows indicate direction of interactions. Green = activation; red = inhibition; and yellow = modulation.