Table 1.

Distribution and scaffold proteins of PKC in representative tissues and blood vessels

PKC	MW (kDa)	Major Tissue Distribution	Blood vessel	Location Inactive PKC	Location Active PKC	Scaffold Protein	Ref
cPKC α	74–82	Universal	Rat aorta	Cytosol	Nuclear	RACK1	[160, 272, 446, 528–531]
			Rat mesenteric artery	Cytosol/Membrane	Cytosol/Membrane	p32
			Rat carotid, ferret portal vein, porcine coronary, bovine aorta	Cytosol	Plasma membrane	RACK1, AKAPs, HSP, p32
β	80–82	Adipose tissue, liver, kidney, spleen, skeletal muscle, brain	Rat aorta	Cytosol	Nuclear	RACK1, p32	[160, 290, 529]
			Rat carotid	Cytosol	Membrane	RACK1, AKAPs, HSP, p32, 14-3-3
γ	70–82	Adrenal gland, brain	Rat mesenteric artery	Cytosol	Cytosol	RACK1, AKAPs, HSP, 14-3-3, Importins	[160, 528, 530]
nPKC δ	76–82	Universal	Rat aorta	Cytoskeleton/Organelles	Cytoskeleton/Organelles	RACK1, p32	[160, 447, 530, 532]
			Rat mesenteric artery	Membrane	Membrane	AKAPs, HSP, p32, 14-3-3
ε	90–97	Pancreas, kidney, brain	Rat mesenteric artery, porcine coronary artery	Cytosol/Membrane	Cytosol/Membrane	AKAPs, p32	[160, 272, 528, 530, 533]
			Ferret aorta	Cytosol	Surface membrane	RACK1, RACK2 AKAPs, HSP, p32, 14-3-3
η	80	Lung, skin, brain	NIH 3T3 fibroblasts	Cytosol/Membrane Golgi	Membrane		[160, 534, 535]
θ	79	T cells, hematopoetic cells, skeletal muscle	cerebral microvascular endothelium	cytosol	Membrane Lipid rafts	AKAPs, HSP, p32, 14-3-3, Importins, CARMA1, Vav1	[160, 221]
aPKC ζ	64–82	Universal	Rat aorta, ferret aorta and portal vein	Perinuclear	Intranuclear	AKAPs, HSP, p32, 14-3-3, Importins	[160, 447, 528, 530, 533]
			Rat mesenteric artery	Cytosol	Cytosol
ι/λ	70	Kidney, testis, ovary, brain	Rabbit femoral artery and portal vein	Cytosol	Cytosol	AKAPs, HSP, 14-3-3, Importins	[160, 536, 537]

MW, molecular weight