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. Author manuscript; available in PMC: 2019 May 17.
Published in final edited form as: Cell Chem Biol. 2018 Mar 22;25(5):585–594.e7. doi: 10.1016/j.chembiol.2018.02.010

Figure 2. NSC319726, 8-hydroxyquinoline, and phenothiazine share similar mechanisms of action against cancer cells.

Figure 2

(A) Left: relative GI50 profiles across the NCI-60 panel against 18 compound clusters representing distinct mechanisms of action of 2,565 cell-line-selective lethal compounds. Right: relative GI50 profiles of 83 compounds in the cluster represented by NSC319726. (B) Four core scaffolds represented in the same cluster as NSC319726. (C) Median sensitivity of the 83 compounds across the NCI-60 panel. See also Figure S2 for the 83 compounds’ structures.