Skip to main content
. Author manuscript; available in PMC: 2019 May 17.
Published in final edited form as: Cell Chem Biol. 2018 Mar 22;25(5):585–594.e7. doi: 10.1016/j.chembiol.2018.02.010

Figure 4. HIF-1α-dependent response to hypoxia induces resistance to NSC319726.

Figure 4

(A) Summary of the pathway enrichment analysis. (B) Effect of hypoxia on NSC319726-induced lethality. Error bars are SEM from sigmoidal curve fitting of a representative experiment. (C) Effect of siHIF-1α on HIF-1α protein level (left) and cellular sensitivity to NSC319726. (D) Chemical induction of HIF-1α and cellular sensitivity to NSC319726. (E) Schematic relationship between NSC319726 and hypoxia. Error bars in (C) and (D) indicate SEM of technical triplicates. See also Figures S3–4.