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. Author manuscript; available in PMC: 2019 Jun 1.
Published in final edited form as: Trends Biochem Sci. 2018 Apr 7;43(6):412–423. doi: 10.1016/j.tibs.2018.03.005

Figure 1. The crystal structure of arrestin-2 in the basal state.

Figure 1

Arrestin-2 (PDB ID: 1G4M) contains two domains, the N- (colored grey) and C-domain (colored blue), which are linked by a hinge region (colored orange). The C-tail (colored pink) of arrestin-2 is attached to the N-domain. One inter-domain contact is the hydrophobic interaction involving β-strand I and the α-helix of the N-domain and the C-tail. It is termed “three-element interaction” and is shown in detail in the upper left box. Another major interaction that holds arrestin-2 in the basal state is the “polar core”, which consists of five charged residues from both domains and the C-tail. It is shown in detail in the upper right box. All participating residues are shown as yellow stick models.