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. Author manuscript; available in PMC: 2019 Jun 1.
Published in final edited form as: Trends Biochem Sci. 2018 Apr 7;43(6):412–423. doi: 10.1016/j.tibs.2018.03.005

Figure 2. The global conformational change of arrestin upon activation.

Figure 2

A. Superposition of the N-domain of active (colored blue, PDB entry 4JQI) and basal (colored grey, PDB entries 1G4M) arrestin-2 highlights the 20° inter-domain rotation. B. Superposition of the N-domain of basal arrestin-2 variants (colored grey and green, PDB entries 1G4M, 1G4R, 1ZSH, 1JSY, 2WTR, 3GD1, 3GC3) reveals a narrower range of rotational movements between domains in the various basal states.