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. Author manuscript; available in PMC: 2018 May 18.
Published in final edited form as: ACS Chem Biol. 2018 Apr 9;13(5):1388–1397. doi: 10.1021/acschembio.8b00293

Figure 1.

Figure 1

Putative copper delivery pathway for cbb3-Cox in Rhodobacter capsulatus. Cu is exported to the periplasm by the P1B-type ATPase CcoI.16,17 Two periplasmic chaperones, PccA and SenC, are required for transfer of the exported Cu to the catalytic subunit CcoN of cbb3-Cox.5 Whether this is a sequential transfer and the directionality of the transfer are unknown. In addition to CcoN, cbb3-Cox in R. capsulatus contains two membrane-bound c-type cyt subunits (CcoO and CcoP) and a small subunit that is required for stability (CcoQ).45 In addition, the assembly factor CcoH is stably associated with the cbb3-Cox complex in Rhodobacter membranes.46