Experiment 1. Effect of repeated restraint stress and repeated SCH-23390 on subsequent active (top) and inactive (bottom) lever pressing during cue- (a) and cocaine priming-induced (b) cocaine seeking. During both cue- and cue + cocaine priming-induced seeking tests, 1-hr sessions began with one non-contingent CS presentation; during the remainder of each session, conditions were identical to those of self-administration training, except that lever presses did not lead to cocaine infusions. EXT indicates the extinction session before seeking tests. *p < .05 and ***p < .001 compared to extinction (a) or 0.0 mg/kg priming condition (b), and #p < .05 compared to saline + unstressed and SCH + unstressed in the 10 mg/kg priming condition, Bonferroni post-test. All data in figure are represented as mean + SEM.