Table 1.
Overall Experimental Design.
| Phase 1: Sucrose Reinforcer | ||||
| Sucrose Preference | Self-Administration FR Acquisition: Restricted | Self-Administration FR Acquisition: Non-Restricted | Self-Administration FR-Dose Response | Self-Administration PR-Dose Response |
| Phase 2: Cocaine Reinforcer | ||||
| Self-Administration FR Acquisition | Self-Administration PR-Escalation | Self-Administration PR-Dose Response | ||
| Phase 3: Choice Between Reinforcers | ||||
| Self-Administration FR Choice | Self-Administration Saline Substitution | |||
| Phase 4: Dopamine Transporter | ||||
| Synaptosomal [3H]DA Uptake | [3H]WIN35,428 Binding | |||