Table 1.
Study outcomes.
| N | No Stretch | Stretch | p value | |
|---|---|---|---|---|
| Tumor volume (mm3)* | 66 | 389 ± 243 | 186 ± 123 | <0.001 |
| Tumor weight (g)* | 66 | 0.21 ± 0.17 | 0.14 ± 0.07 | 0.02 |
| Animal weight (g)*§ | 66 | 21.3 ± 1.6 | 20.7 ± 1.0 | 0.05 |
| Soluble cytokines (pg/ml)# | ||||
| IL-2 | 28 | 14.3 (7.5–26.6) | 18.1(11.0–22.6) | 0.81 |
| IL-6 | 54 | 25.6 (4.5–91.4) | 46.1 (21.1–95.5) | 0.18 |
| IL-10 | 54 | 102.1 (16.9–245.5) | 159.3 (24.3–642.9) | 0.35 |
| TNF-α | 54 | 15.5 (2.6–30.3) | 25.1 (9.9–52.3) | 0.18 |
| INF-γ | 54 | 29.0 (2.4–63.9) | 39.9 (12.7–93.6) | 0.24 |
| SPMs (pg/ml)# | ||||
| RvD1 | 20 | 4.4 (1.5–21.7) | 31.6 (10.9–61.2) | 0.02 |
| RvD2 | 20 | 10.9 (3.7–56.8) | 95.4 (16.4–238.5) | 0.04 |
| Cellular Receptors | ||||
| Macrophages (%)* | ||||
| CD64+ (M1) | 20 | 49.9 ± 24.8 | 51.0 ± 11.8 | 0.90 |
| CD206+ (M2) | 20 | 44.3 ± 22.1 | 45.2 ± 13.2 | 0.91 |
| T lymphocytes (%)* | ||||
| CD3+ | 46 | 80.2 ± 17.9 | 77.1 ± 20.4 | 0.59 |
| CD4+ | 46 | 77.0 ± 8.1 | 82.3 ± 4.7 | 0.10 |
| CD8+ | 46 | 51.0 ± 30.0 | 43.4 ± 32.9 | 0.10 |
| PD1+CD8+ | 46 | 20.7 ± 15.1 | 13.4 ± 7.38 | 0.04 |
| Cytokines (%CD8+ cells)# | ||||
| IL-2 | 8 | 3.8 (2.3–6.7) | 8.8 (7.3–9.1) | 0.04 |
| TNF-α | 8 | 4.0 (2.1–6.2) | 7.7 (5.5–7.9) | 0.08 |
| INF-γ | 8 | 2.9 (0.9–5.8) | 3.9 (1.2–6.4) | 0.77 |
*Mean ± Standard Deviation.
#Median (Interquartile range).
§Total tumor weight was subtracted from the weight of each animal.
N represents total number of animals with equal number of stretch and no stretch.
CD64+ and CD206+ and CD3+ are expressed as a percentage of all leukocytes;
CD4+ and CD8+ are expressed as a percentage of TCR+ lymphocytes; PD1+CD8+ are expressed as a percentage of CD8+ lymphocytes.