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. 2018 May 18;8:7876. doi: 10.1038/s41598-018-26244-4

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Functional annotation of PGC-1α/NT-PGC-1α ChIP-seq peaks. (A) The highest scoring sequence motif compiled from PGC-1α/NT-PGC-1α binding peaks within a 600-bp window centered on the binding summits. (B) Transcription factor binding enrichment from the PGC-1α/NT-PGC-1α ChIP-seq. The top eight most enriched motifs identified using the SeqPos motif tool from Galaxy Cistrome. ESRRB (ERR beta), ESRRA (ERR alpha), NR4A1 (NUR77, TR3), NR5A2 (LRH-1, FTF), NR2F2 (TFCOUP2), NR4A2 (NURR1), NR1H4 (FXR), NR2F1 (COUP-TF1), NR1D2 (Rev-Erb), NR0B1 (DAX1), NR6A1 (RTR), NR1I2 (PXR), ESRRG (ERR gamma), and NR1H2 (LXRB). (C) Functional enrichment analysis of PGC-1α/NT-PGC-1α peaks using GREAT. Top ten ranked biological processes (GO biological process) and signaling pathways (MsigDB pathway) of genes associated with PGC-1α and NT-PGC-1α peaks are shown.