. 2018 Apr 26;118(10):1296–1301. doi: 10.1038/s41416-018-0074-1

Table 4.

Association between SNPs with p < 0.1 in the univariable analysis and endpoints (exploration cohort)

Endpoint	Factor	Genotype	Univariable		Multivariable
			OR (95% CI)	p-value	OR (95% CI)	p-value
Decreased renal clearance (≥grade 2)	Age				1.056 (0.999–1.116)	0.056
	Gender (f. vs. m.)				1.364 (0.555–3.350)	0.498
	PDCD1 804C>T	CC → CT → TT ^a	1.631 (0.917–2.903)	0.096^b	1.545 (0.864–2.763)	0.142
Elevated transaminases (any grade)	Age				1.010 (0.967–1.055)	0.649
	Gender (f. vs. m.)				1.741 (0.841–3.604)	0.135
	PTPN11 333–223A>G	GG + AG vs. AA	2.309 (1.024–5.208)	0.041^c	2.421 (1.061–5.523)	0.036
Hypothyroidism or hyperthyroidism (any grade)	Age				0.989 (0.950–1.030)	0.598
	Gender (f. vs. m.)				1.158 (0.579–2.315)	0.678
	PTPN11 333–223A>G	GG + AG vs. AA	0.395 (0.158–0.985)	0.061^d	0.403 (0.161–1.007)	0.052
Treatment-related adverse events (any grade)	Age				1.007 (0.967–1.049)	0.738
	Gender (f. vs. m.)				1.234 (0.609–2.498)	0.560
	PDCD1 804C>T	TT vs. CC + CT	0.454 (0.211–0.978)	0.041^c	0.440 (0.202–0.958)	0.039
Rheumatological toxicity (any grade)	IFNG -1616T>C^e	CC vs. TT + TC	6.044 (1.531–23.857)	0.019^d

OR odds ratio, CI confidence interval, f. vs. m. females versus males.

^aAdditive model was used.

^bLogistic regression was used.

^cChi-square test was used.

^dFisher’s Exact test was used.

^eOnly tested univariably due to the number of events