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. 2018 May 18;8:7860. doi: 10.1038/s41598-018-26128-7

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Plasma membrane ABC transporters of S. cerevisiae involved in lipid trafficking. Schematic representation of a set of ABC transporters that localize to the plasma membrane and are documented to play physiological roles in lipid trafficking and homeostasis in S. cerevisiae^7,8,16–21. Pdr18, Pdr11, Aus1, Pdr10 and Pdr5 belong to the pleiotropic drug resistance (PDR) subfamily, Yor1 belongs to the multidrug resistance-associated protein (MRP) subfamily and Ste6 belongs to the multidrug resistance (MDR) subfamily of ABC transporters. The proposed biological functions are detailed in the Introduction section. Ergosterol transport, from its site of synthesis to the plasma membrane, is considered to occur by equilibration (t_1/2 ~ 10–15 min) of endoplasmic reticulum and plasma membrane ergosterol pools via a bidirectional, nonvesicular process⁶⁶. Abbreviations: phosphatidylcholine (PC), phosphatidylserine (PS), phosphatidylethanolamine (PE).