Table 3.
Predicted miR-92a target genes and their impact on atherosclerosis via PicTar.
| Gene symbol | Gene Name | Impact on Atherosclerosis | Reference (inter alia) |
|---|---|---|---|
| USF2 | Upstream Transcription Factor 2 | related to familial hypercholsteremia | Chen et al., 2014, Int J Mol Med. |
| MEF2D | Myocyte Enhancer Factor 2D | regulates proliferation of VSMCs | Zhao et al., 2002, Arch Biochem Biophys. |
| GDF11 | Growth Differentiation Factor 11 | protects against endothelial cell injury | Mei et al., 2016, Mol Ther. |
| RGS3 | Regulator of G-protein Signalling 3 | protects against pathological changes of adventitial fibrobloasts | Xu et al., 2017, Cell Biochem Funct. |
| KLF2 | Kruppel-Like Factor 2 | modulated endothelial homeostasis, vasoregulation, vascular growth/remodeling, and inflammation | Novodvorsky et al., 2014, Prog Mol Biol Transl Sci. |
| NADPH Oxidase | NicotinAmidadenindinucleotidPhosphat Oxidase | impact on vascular oxidative stress | Di Pietro et al., 2017, Int J Mol Sci. |
| TRAF3 | Tumor necrosis factor Receptor-Associated Factor 3 | modulates CD40 signaling in atherogenesis | Zirlik et al., 2007, Arterioscler Thromb Vasc Biol. |
| CD51 | CD51 | expressed on endothelial microparticles | Arteaga et al., 2006, Am J Cardiol. |
| GRK5 | G protein-coupled Receptor Kinase-5 | attenuates atherosclerosis by regulating receptor tyrosine kinases | Wu et al., 2012, Arterioscler Thromb Vasc Biol. |
| Adrenomedullin | adrenomedullin | marker of carotid plaques | Gottsäter et al., 2013, J Hypertens. |
| KLF4 | Kruppel-Like Factor 2 | promotes transition of VSMC phenotype | Shankman et al., 2015, Nat Med. |
| MYCBP2 | Myc Binding Protein 2 | suppresses M2-like phenotypes in macrophages | Pierre et al., 2017, Eur J Immunol. |
| RYR3 | Ryanodine Receptor 3 | RYR3 gene polymorphisms associates with atherosclerosis | Zhao et al., 2014, BMC Cardiovasc Disord. |
| CREB1 | Cyclic adenosine monophosphate Response Element-Binding protein | enhances interleukin-17A production and inflammation | Kotla et al., 2013, Sci Signal. |
| COL1A2 | Collagen 1A2 | enhanced expression in human aortal intima during atherogenesis | Shchelkunova et al., 2013, Biochemistry (Mosc). |
| GATA6 | GATA binding protein 6 | regulates adehsion moleculaes in endothlial cells | Tsoyi et al., 2010, Atherosclerosis. |
| NFAT5 | Nuclear Factor of Activated T-cells 5 | drives macrophage migration | Halterman et al., 2012, Front Physiol. |
| ITR | Inotocin Receptor | enhances VSMC hyperplasia | Kang et al., 2015, PLoS One. |
| PKCε | Protein Kinase C epsilon | inflammation and smooth muscle cell dysfunction | Raghuraman et al., 2016, Atherosclerosis. |
| PAF-AH | Platelet-Activating Factor AcetylHydrolase | modulation of inflammation and plaque formation | Karabina et al., 2010, Biochimie |