Table 1.

The classification of DS is more accurate on only European or African patients. These marked differences cannot be observed for ML, MPS I, MPS II, SLOS, and NCBRS. Also, the restriction to only male patients has only a minor effect on the performance. The difference of MCCs for the binary classification of every disease was normalized by the standard deviations of MCCs that were computed in the mixed controls

	pt. confounder	DS	pt. confounder	ML	MPS I	MPS II	SLOS	NCBRS
	CEU vs mixed:	2.7	CEU vs mixed:	−0.7	1.53	−0.29	0.31	0.77
ΔΜCC-STD	AFR vs mixed:	3.75	male vs mixed:	0.14	0.13	1.17	1.84	1.12