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. 2018 Jan 18;194(6):560–569. doi: 10.1007/s00066-018-1262-x

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© The Author(s) 2018

Open Access This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.

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Fig. 1 — Commonly used risk-adapted dose prescription based on PTV size and its effect on exceeding the normal tissue constraint for radionecrosis risk V_12Gy = 10 cm³. The V_12Gy as function of GTV size is presented for different GTV-PTV margins and beam arrangements. Legend: GTV gross tumor volume, PTV planning target volume, V_12Gy volume of healthy brain tissue which is irradiated to 12 Gray or more. The GTV-PTV margin: 0 mm (a), 1 mm (b), and 2 mm (c). The open and filled symbols represent non-coplanar and coplanar beams, respectively. The single-fraction PTV size-based dose prescription: 24 Gy (triangle), 21 Gy (square), 18 Gy (diamond), and 15 Gy (circle)