Table 3.
Cox regression analysis for eary RFS in 205 patients with resectable HCC
| Univariate analysis | Multivariable analysis | |||||||
|---|---|---|---|---|---|---|---|---|
| 95.0% CI | 95.0% CI | |||||||
| P-value | HR | Lower | Upper | P-value | HR | Lower | Upper | |
| 5-gene score (poor vs. good group) | 0.023 | 2.087 | 1.106 | 3.936 | 0.361 | 1.373 | 0.696 | 2.708 |
| Age (> = 60 vs. < 60) | 0.469 | 1.113 | 0.833 | 1.488 | ||||
| HBV | 0.814 | 1.079 | 0.572 | 2.035 | ||||
| HCV | 0.044 | 1.476 | 1.010 | 2.156 | ||||
| NBNC | 0.100 | 0.772 | 0.567 | 1.051 | ||||
| Tumor Nodules | 0.000 | 5.308 | 2.474 | 11.390 | 0.000 | 5.956 | 2.554 | 13.892 |
| Cirrhosis (Yes vs. No) | 0.223 | 1.418 | 0.809 | 2.485 | ||||
| VI (Yes vs. No) | 0.009 | 2.131 | 1.21 | 3.754 | 0.904 | 0.959 | 0.483 | 1.901 |
| Tumor size (> = 5 cm vs < 5 cm) | 0.012 | 2.053 | 1.169 | 3.604 | 0.058 | 1.885 | 0.978 | 3.634 |
| Edmonson Grade | 0.985 | 0.997 | 0.74 | 1.344 | ||||
| AFP level (Normal (< 20) vs. elevated) | 0.001 | 3.192 | 1.631 | 6.248 | 0.004 | 2.823 | 1.387 | 5.745 |
| RB1 mutation | 0.009 | 2.62 | 1.27 | 5.413 | 0.488 | 1.318 | 0.604 | 2.873 |
| TP53 mutation | 0.769 | 1.094 | 0.602 | 1.987 | ||||
| CTNNB1 mutation | 0.338 | 0.702 | 0.341 | 1.447 | ||||
*VI Microvascular Invasion