Table 2.
Subgroup analyses of overall graft failure associated with HLA per mismatch and HLA-DR mismatches
| HLA per mismatch | HLA-DR mismatches | |||||||
|---|---|---|---|---|---|---|---|---|
| Subgroup | No. of recipients (cohorts) | HR (95% CI) | I 2 | P a | No. of recipients (cohorts) | HR (95% CI) | I 2 | P a |
| Sample size | 0.835 | 0.011 | ||||||
| ≥10,000 | 281,141 (5) | 1.06 (1.05–1.07) | 49.1 | 145,351 (2) | 1.07 (1.04–1.10) | 0 | ||
| < 10,000 | 8614 (7) | 1.06 (1.03–1.09) | 17.3 | 4652 (5) | 1.27 (1.12–1.43) | 48.4 | ||
| Nature of data | 0.133 | 0.076 | ||||||
| Univariable-unadjusted | 1440 (4) | 1.14 (1.04–1.26) | 24.8 | 2598 (2) | 1.39 (1.05–1.83) | 70.0 | ||
| Multivariable-adjusted | 286,755 (12) | 1.06 (1.05–1.07) | 27.4 | 150,003 (7) | 1.08 (1.05–1.11) | 58.3 | ||
| Data source | 0.683 | 0.011 | ||||||
| Registry/Multi-center | 286,283 (6) | 1.06 (1.05–1.07) | 38.9 | 145,351 (2) | 1.07 (1.04–1.10) | 0 | ||
| Single-center | 3472 (6) | 1.07 (1.02–1.12) | 26.6 | 4652 (5) | 1.27 (1.12–1.43) | 48.4 | ||
| Donor source | 0.027 | 0.616 | ||||||
| Cadaveric | 138,516 (5) | 1.07 (1.06–1.07) | 0.00 | 41,284 (5) | 1.08 (1.04–1.11) | 66.4 | ||
| Living and Cadaveric | 151,239 (7) | 1.05 (1.05–1.06) | 16.4 | 108,719 (2) | 1.09 (1.04–1.15) | 55.4 | ||
| Geographical locations | 0.053 | 0.033 | ||||||
| Europe | 138,988 (6) | 1.07 (1.06–1.08) | 0.00 | 1952 (4) | 1.32 (1.09–1.60) | 59.7 | ||
| North America | 137,880 (4) | 1.05 (1.04–1.06) | 2.1 | 145,351 (2) | 1.07 (1.04–1.10) | 0 | ||
| Asia | 225 (1) | 1.24 (1.00–1.55) | – | 2700 (1) | 1.23 (1.05–1.45) | – | ||
| Oceania | 12,662 (1) | 1.07 (1.03–1.12) | – | 0 | – | – | ||
| Year period | 0.175 | 0.026 | ||||||
| Prior to 1995 | 103,915 (6) | 1.06 (1.05–1.07) | 0.00 | 148,051 (3) | 1.08 (1.04–1.12) | 26.8 | ||
| Not prior to 1995 | 185,626(5) | 1.06 (1.05–1.08) | 60.1 | 4054 (4) | 1.36 (0.98–1.88) | 59.7 | ||
| NR | 214 (1) | 0.83 (0.51–1.34) | – | – | – | – | – | – |
The effect estimates were stratified for sample size (≥10,000 vs < 10,000), data source (multi-centered vs single-centered), donor source (cadaveric vs living and cadaveric), geographic locations (European, North America, Asia and Oceania) and year period (prior to 1995 vs not prior to 1995)
aP value for heterogeneity