Table 1.
Known cellular receptors for different AAV serotypes
| Serotype | Glycan recognitiona | Coreceptor |
|---|---|---|
| AAV1 | Neu5Acα2-3GalNAcβ1-4GlcNAc | Unknown |
| AAV2 | 6-O- and N-sulfated heparin | Fibroblast [108]/hepatocyte [109] growth factor receptor; laminin receptor [110]; integrin αVβ5 [111] and α5β1 [112] |
| AAV3 | 2-O- and N-sulfated heparin | Hepatocyte growth factor receptor [113]; Laminin receptor [110] |
| AAV4 | Galβ1-4GlcNAcβ1-2Manα1-6Manβ1-4GlcNAcβ1-4GlcNAc | Unknown |
| AAV5 | Neu5Acα2-3(6S)Galβ1-4GlcNAc | Platelet-derived growth factor receptor [114] |
| AAV6 | Neu5Acα2-3GalNAcβ1-4GlcNAc; N-sulfated heparin | Epidermal growth factor receptor [115] |
| AAV7 | Unknown | Unknown |
| AAV8 | Unknown | Laminin receptor [110] |
| AAV9 | Galactose [116] | Laminin receptor [110] |
aAll glycan recognitions listed, except for AAV9, are from a study by Mietzsch et al. [117] and are more specific glycans compared to the original publications identifying the primary glycans recognized by each serotype