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. 2018 May 18;18:570. doi: 10.1186/s12885-018-4294-9

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© The Author(s). 2018

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 2 — Kaplan-Meier survival patients with hilar cholangiocarcinoma based on ADAM-28, ADAM-10, and ADAM-17 expression. a, b, c Cancer overexpressing ADAM-28 (A), ADAM-10 (B), and ADAM-17 (C) showed a higher chance for recurrence than those who did not (ADAM-28: Neg. vs. Pos.: 26mon vs. 15mon, P = 0.050; ADAM-10: Neg. vs. Pos.: 41mon vs. 17mon, P = 0.020; AD1 M-17: Neg. vs. Pos.: 39mon vs. 17mon, P = 0.010). (A1, B1, C1) Patients overexpressing ADAM-28 (A1), ADAM-10 (B1), and ADAM-17 (C1) showed a decreased survival duration compared to patients who did not (ADAM-28: Neg. vs. Pos.: 26mon vs. 17mon, P = 0.074; ADAM-10: Neg. vs. Pos.: 50mon vs. 17mon, P = 0.010; AD1 M-17: Neg. vs. Pos.: 42mon vs. 15mon, P = 0.003)