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. 2018 May 18;18:569. doi: 10.1186/s12885-018-4451-1

Fig. 2.

Fig. 2

Sensitivity heat maps of the SMO network. Sensitivity was calculated in response to variations in SMO and PI3K activities on the xy-plane (left and right, respectively), combined with different levels of cAMP (as in Fig. 1) on the z-axis. The regions of high sensitivity between low and high SMO and PI3K activities (blue-red-yellow areas) correspond to a transition zone between low and high steady-state activity of tumour proliferation