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. 2018 May 18;18:569. doi: 10.1186/s12885-018-4451-1

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© The Author(s) 2018

Open Access This article is distributed under the terms of the Creative Commons Attribution 4.0 International License(http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver(http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 2 — Sensitivity heat maps of the SMO network. Sensitivity was calculated in response to variations in SMO and PI3K activities on the xy-plane (left and right, respectively), combined with different levels of cAMP (as in Fig. 1) on the z-axis. The regions of high sensitivity between low and high SMO and PI3K activities (blue-red-yellow areas) correspond to a transition zone between low and high steady-state activity of tumour proliferation