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Known resistance mutations in the SMO domain. Source: COSMIC http://cancer.sanger.ac.uk/cosmic[16]
| Mutation | Number | Associated with |
|---|---|---|
| of samples | BCC initiation | |
| H231R | 2 | Yes |
| T241M | 1 | No |
| W281C | 2 | Yes |
| W281L | 1 | No |
| V321A | 1 | Yes |
| V321M | 3 | Yes |
| A459V | 3 | Yes |
| F460L | 1 | Yes |
| C469Y | 1 | No |
| D473G | 7 | Yes |
| D473H | 2 | Yes |
| D473N | 1 | Yes |
| D473Y | 1 | No |
| Q477E | 1 | Yes |
| G497W | 3 | Yes |
| S533N | 1 | Yes |
| W535L | 10 | Yes |
| W535R | 1 | Yes |
