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. 2018 May 18;11:67. doi: 10.1186/s13045-018-0615-3

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© The Author(s). 2018

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 3 — Wnt signaling in hematopoietic stem cells and early B cell development. Wnt signaling is essential for HSC self-renewal capacity and is also active in precursor cells from fraction A. Fraction B pro-B cells, that undergo IgH rearrangement, have an active Wnt pathway and express high levels of LEF1 and Fzd9. Also, large pre-B cells from fraction C that greatly expand their population express LEF1 and Fzd9 and have an active Wnt pathway. Small pre-B cells from fraction D stop proliferating and start rearranging IgL genes. Upon expression of IgM, Wnt pathway activity is expected to be terminated