Supplementary Table 1.

Neuropsychological test battery.

Task	Domain	Explanation
Mini Mental State Examination (MMSE) [16]	Global measure of cognition	This test includes 30 simple questions and tasks related to several topics (orientation in time and place, repetition and recall of a list of words, arithmetic, language use and comprehension, and non-verbal memory). The summary score was analyzed
Rey Auditory Verbal Learning Test (RAVLT) [16]	Verbal memory, learning, recall efficiency	A list of 15 meaningful monosyllabic words is presented in 5 trials. Each trial ends with a free recall of the words (immediate recall). After a period of 20 min following the 5th trial, the participant is requested to recall as many words as possible (delayed recall). The main variables used are the total number of correct words in the 5 immediate trials and the total number of correct words in the delayed recall trial
Wechsler Memory Scale (WB sp) – Visual Memory Span [16] WB sp-Digit Span Forward [16] WB sp-Digit Span Backward [16]	Visual short-term memory Attention, short-term memory Attention, working memory	This test requires subjects to reproduce a series of three geometric shapes from memory after 10 sec of exposure to the shapes. Increasingly long sequences of random numbers are read to the participant, who is then asked to recall the sequence. This test terminates when a participant fails to recall two sequences of the same length. In the backward subtest, participants must repeat the number sequence in reverse order
Symbol Digit Modalities Test (SDMT) [16]	Psychomotor speed, attention	The participant must fill in blanks according to a key in which a symbol corresponds to a digit. The number of filled blanks within 90 sec is recorded
Trail Making Test A (TMT A) [16]	Psychomotor speed, attention, concentration	The participant must draw a trail with a pencil, connecting the numbered circles in numerical order. The time to complete the task was analyzed
PsychE-simple reaction time [17]	Psychomotor speed, reaction time	The subject holds down the spacebar on the keyboard. After a random interval of 1–10 sec, a small ‘sun’ icon appears at a random position on the screen. The subject is required to lift his or her finger as quickly as possible from the spacebar and use it to press numeric key 4. For each response, the total reaction time is recorded with an accuracy of 1 ms