Table 1. The top 5 enriched GO terms of the up-regulated DEGs.

Category	ID	Term	Gene count	P value
BP	GO:0006955	immune response	29	2.18E−08
	GO:0006954	inflammatory response	20	1.87E−04
	GO:0045087	innate immune response	19	6.05E−06
	GO:0043123	positive regulation of I-kappaB kinase/NF-kappaB signaling	14	0.014345
	GO:0010628	Positive regulation of gene expression	14	0.048003
CC	GO:0070062	extracellular exosome	183	3.16E−13
	GO:0005615	extracellular space	78	2.95E−10
	GO:0016020	membrane	54	0.017266
	GO:0005829	cytosol	48	0.037259
	GO:0005783	endoplasmic reticulum	34	0.002373
MF	GO:0005524	ATP binding	81	0.001476
	GO:0004197	cysteine-type endopeptidase activity	9	2.26E−04
	GO:0030246	carbohydrate binding	9	0.031484
	GO:0004888	transmembrane signaling receptor activity	7	0.006525
	GO:0016301	kinase activity	6	0.009682

Notes.

GO

gene ontology

BP

biological process

MF

molecular function

CC

cellular component

p-value < 0.05 was considred as threshold values of significant differences.