Table 2. The top 5 enriched GO terms of the down-regulated DEGs.
| Category | ID | Term | Gene count | P value |
|---|---|---|---|---|
| BP | GO:0070374 | positive regulation of ERK1 and ERK2 cascade | 12 | 0.024691 |
| GO:0043065 | positive regulation of apoptotic process | 12 | 0.027999 | |
| GO:0002062 | chondrocyte differentiation | 8 | 3.70E−04 | |
| GO:0006874 | cellular calcium ion homeostasis | 8 | 0.002072 | |
| GO:0007224 | smoothened signaling pathway | 8 | 0.018141 | |
| CC | GO:0070062 | extracellular exosome | 123 | 0.002059 |
| GO:0005737 | cytoplasm | 118 | 0.013056 | |
| GO:0005615 | extracellular space | 44 | 0.028228 | |
| GO:0005925 | focal adhesion | 25 | 0.005367 | |
| GO:0009986 | cell surface | 23 | 0.018489 | |
| MF | GO:0005509 | calcium ion binding | 38 | 0.001071 |
| GO:0008201 | heparin binding | 13 | 1.59E−04 | |
| GO:0004725 | protein tyrosine phosphatase activity | 9 | 0.037067 | |
| GO:0008144 | drug binding | 7 | 0.003298 | |
| GO:0017046 | peptide hormone binding | 4 | 0.00765 |
Notes.
- GO
- gene ontology
- BP
- biological process
- MF
- molecular function
- CC
- cellular component
p-value < 0.05 was considred as threshold values of significant differences.