| Up-regulated |
Cytokine-cytokine receptor interaction |
32 |
4.04E−06 |
CSF2, IL1R2, TNFRSF21, TNF, CCL2, CCR1, CXCL8, IL15, IL7R, CCL4, IL17RA, CXCL10, TNFRSF11B, CXCR4, IFNG, IL1B, FAS, XCR1, LTB, IFNGR2, IL1A, IL4, IL18R1, IL6, TNFSF4, LTBR, TGFBR1, LOC100348776, CCR8, TNFSF10, TNFSF13B, CCR2 |
|
TNF signaling pathway |
19 |
1.11E−05 |
PIK3CG, CSF2, IL18R1, IL6, CCL2, TNF, MMP9, CREB1, IL15, MMP3, BIRC3, CXCL10, VCAM1, NOD2, MAPK14, IL1B, CREB3L1, FAS, TRAF3 |
|
Cell cycle |
19 |
3.93E−04 |
CDC6, CDK1, TTK, CHEK1, RB1, MCM4, YWHAE, MCM6, CCNE2, CCNE1, YWHAG, CCNB2, MCM7, MAD2L1, PCNA, BUB1B, ORC6, CCNA2, BUB3 |
|
Toll-like receptor signaling pathway |
15 |
5.71E−04 |
PIK3CG, IL6, TNF, LY96, TLR2, LOC100348776, CXCL8, TLR4, CCL4, CXCL10, IKBKE, CD80, MAPK14, IL1B, TRAF3 |
|
DNA replication |
8 |
0.002306 |
POLD3, MCM7, SSBP1, POLE, PCNA, MCM4, RPA3, MCM6 |
|
Chemokine signaling pathway |
19 |
0.007327 |
PIK3CG, LOC100008716, CCL2, VAV3, NCF1, HCK, CCR1, STAT5B, CXCL8, LOC100348776, CCL4, CXCL10, CCR8, CXCR4, CCR2, GNB4, XCR1, PLCB2, LOC100349255 |
|
Cell adhesion molecules (CAMs) |
16 |
0.017244 |
CADM1, SELL, NECTIN1, LOC100351865, VCAM1, ALCAM, CD80, RLA-DRB1, ICOS, ITGB7, CD274, LOC100350168, CD2, VCAN, LOC100343144, CD226 |
| Down-regulated |
cGMP-PKG signaling pathway |
16 |
0.003361 |
ROCK1, GNAI1, MYLK3, MRVI1, ATP1A2, PRKG1, MYL9, AGTR1, EDNRB, KCNJ8, PLN, PDE5A, GUCY1A2, GUCY1B3, MYLK, PIK3R1 |
|
TGF-beta signaling pathway |
11 |
0.003933 |
BMP4, BMP2, LTBP1, ROCK1, ZFYVE9, LOC100008826, BMPR1B, MYC, BMP5, TGFB2, ACVR1C |
|
MAPK signaling pathway |
20 |
0.004435 |
EGFR, FGFR1, MRAS, CACNB1, DUSP10, CACNB2, FGF10, CACNB3, FGF12, MECOM, TGFB2, MAP3K6, FOS, RASGRP3, DUSP1, MAP3K1, MYC, FGF2, GADD45A, CACNA1A |
|
Renin-angiotensin system |
5 |
0.00852 |
AGTR1, AGTR2, ACE, ACE2, MME |
|
Vascular smooth muscle contraction |
12 |
0.012552 |
AGTR1, ACTG2, ROCK1, MYLK3, CALD1, MRVI1, GUCY1A2, GUCY1B3, PRKG1, PLA2G2D, MYLK, MYL9 |
|
Focal adhesion |
16 |
0.01614 |
EGFR, CAV2, COL4A2, ROCK1, MYLK3, ITGA2, CAPN2, COL4A5, MYL9, VEGFC, ITGA6, ITGB8, PIK3R1, MYLK, THBS3, SHC4 |
|
PI3K-Akt signaling pathway |
22 |
0.016374 |
EGFR, FGFR1, COL4A2, RBL2, EFNA1, ITGA2, FGF10, FGF12, COL4A5, VEGFC, ITGA6, PRLR, ITGB8, EPOR, MTCP1, PPP2R2B, MYC, ANGPT2, FGF2, PIK3R1, THBS3, GHR |
