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(A) General description of the pipeline developed in this work to identify and validate N- or C-terminal extensions. (B) Example of 9-mer motifs identified in HLA peptidomics data from Mel_15 (16). The number of peptides assigned to each motif is shown in parentheses. (C) Illustration of the different models built from the 9-mer motifs (bulge, C- and N-terminal extension) to investigate noncanonical binding modes among 10-mers.
