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. 2018 Apr 30;115(20):5083–5088. doi: 10.1073/pnas.1717277115

Fig. 4.

Fig. 4.

(A) New crystal structure of HLA-A68:01 (white ribbon) in complex with a C-terminally extended ligand (yellow) superimposed with HLA-A68:01 (green ribbon) in complex with a canonical 9-mer ligand (blue, PDB ID code 4WHZ) (29). (B) Comparison of HLA-A68:01 (white ribbon) in complex with a C-terminally extended ligand (yellow) and the complex of HLA-A02:01 (pink ribbon) bound to a C-terminal extended 12-mer peptide (FVLELEPEWTVK, magenta, PDB ID code 5DDH) (9). (C) HLA-I residues surrounding the C terminus of canonical ligands and displaying the largest Jensen–Shannon divergence between alleles with C-terminal extensions (Top Left) and alleles without C-terminal extensions (Bottom Left). For comparison, the sequence logos of HLA-A (Top Right) and HLA-B/C (Bottom Right) alleles at the same positions are displayed. (D) Analysis of the distance D80–143 for alleles with available crystal structures (SI Appendix, Table S1). Green lines correspond to alleles displaying C-terminal extensions. The orange line represents HLA-A02:01.