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LC-MS/MS–based lipidomics shows that HFD treatment increases concentrations of sEH-produced fatty acid diols in colon tissues. (A) Loading plot analysis shows that sEH-produced fatty acid diols contribute to the differentiation of eicosanoid profiles in LFD and HFD groups. (B) Concentrations of sEH-produced fatty acid diols and COX-produced prostaglandins in colon tissues. The results are mean ± SEM; n = 8 to 10 mice per group.
