Table 3.

Discrimination of PSA (ng/ml), age with free and total PSA, and age with the four kallikrein panel for predicting death from prostate cancer

PSA subgroup	N	Prostate cancer death N	Model	C-index	Difference from PSA alone	95% CI
PSA < 1.0	5734	28	Total PSA	0.628	–	–
			Age + free and total PSA	0.625	–0.003	–0.163, 0.160
			Kallikrein panel	0.683	0.055	–0.091, 0.191
PSA ≥ 0.0	11 506	317	Total PSA	0.862	–	–
			Age + free and total PSA	0.819	–0.043	–0.069, –0.016
			Kallikrein panel	0.864	0.003	–0.020, 0.023
PSA ≥ 1.0	5772	289	Total PSA	0.800	–	–
			Age + free and total PSA	0.806	0.005	–0.024, 0.033
			Kallikrein panel	0.840	0.039	0.012, 0.062
PSA ≥ 1.5	3561	267	Total PSA	0.747	–	–
			Age + free and total PSA	0.782	0.035	0.002, 0.069
			Kallikrein panel	0.818	0.071	0.042, 0.102
PSA ≥ 1.8	2888	250	Total PSA	0.730	–	–
			Age + free and total PSA	0.766	0.036	0.004, 0.069
			Kallikrein panel	0.800	0.070	0.040, 0.103
PSA ≥ 2.0	2556	233	Total PSA	0.735	–	–
			Age + free and total PSA	0.767	0.031	0.001, 0.065
			Kallikrein panel	0.803	0.067	0.040, 0.102
PSA ≥ 3.0	1455	184	Total PSA	0.720	–	–
			Age + free and total PSA	0.750	0.029	0.000, 0.060
			Kallikrein panel	0.785	0.065	0.034, 0.099
PSA ≥ 3.5	1152	174	Total PSA	0.685	–	–
			Age + free and total PSA	0.741	0.056	0.021, 0.090
			Kallikrein panel	0.775	0.090	0.053, 0.125

CI = confidence interval; PSA = prostate-specific antigen.