Skip to main content
. Author manuscript; available in PMC: 2018 May 19.
Published in final edited form as: Anal Chem. 2018 Jan 8;90(3):1870–1880. doi: 10.1021/acs.analchem.7b03949

Figure 6.

Figure 6

Application of the T-μLC-MS in the quantification of a circulating biomarker and biotherapeutic or target antigen in tissues. (a) Quantification of cardiac troponin I (cTnI) levels in swine plasma after a brief, reversible myocardial ischemia (n = 4). (b) cTnI release from a myocardial infarction model is used as positive control. Time courses of (c) mAb cT84.66 and (d) carcinoembryonic antigen (CEA), the target of the mAb, in an MC38CEA+ tumor from a C57BL/6 mouse model after a low (0.5 mg/kg), single IV injection.