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. Author manuscript; available in PMC: 2018 May 19.
Published in final edited form as: Anal Chem. 2018 Jan 8;90(3):1870–1880. doi: 10.1021/acs.analchem.7b03949

Table 1.

Model Proteins and Signature Peptides

protein name type matrix signature peptidea pIb GRAVYc
FcRn receptor, human rat liver DVNVIPATA 3.80   0.80
anti-HCV humanized IgG rat liver TVAAPSVFIFPPSDEQLK 4.37   0.24
cardiac troponin I (cTnI) circulating biomarker, swine swine plasma NITEIADLNQK 4.37 −0.68
IL-33 biomarker, human rat tumor TDPGVFIGVK 5.50   0.52
CD30 cell-membrane biomarker, human rat tumor QCEPDYYLDEAGR 3.92 −1.42
cT84.66 murine IgG mouse tumor ASNLESGIPVR 6.05   0.07
anti-TNFα murine IgG rat plasma EFQLQQSGPELVKPGASVR 6.24 −0.57
C-reactive protein (CRP) circulating biomarker, human rat plasma GYSIFSYATK 8.50 −0.01
carcinoembryonic antigen (CEA) biomarker, human mouse tumor TLTLISVTR 9.40   0.91
AB095 humanized IgG rat plasma GPSVFPLAPSSK 8.75   0.09
a

Signature peptides (SPs) were selected experimentally with a previously reported method on the basis of uniqueness, sensitivity, stability, etc.14,15,33

b

pI values were calculated with a tool from https://web.expasy.org/compute_pi/

c

Grand-average-of-hydropathy (GRAVY) values were acquired with a tool by Dr. Stephan Fuchs (http://www.gravy-calculator.de).