Fig. 1.

Distribution of functionally evaluated GRIN1, GRIN2A, and GRIN2B mutations/variants associated with epilepsy. ATD, amino-terminal domain (blue); LBD-S1 and LBD-S2, the first and second polypeptide sequences comprising the LBD (green); 1, 2, 3, and 4, transmembrane domains (purple); CTD, carboxyl-terminal domain (pink). Linker regions (S1-M1 linker, M3-S2 linker, and S2-M4 linker) are in yellow. Mutations with gain-of-function effects, loss-of-function effects, and unchanged effects are indicated in red, green, and blue, respectively