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AATYK is up-regulated during remyelination. In situ hybridization with MBP (A, B) or PLP probes (D, E) showed severe demyelination of the corpus callosum in wild-type mice after 6 weeks of cuprizone treatment as compared to untreated animals. Compared with the recovered expression of MBP and PLP (C, F), AATYK was observed in the corpus callosum of mice after recovery for 2 weeks (G, H, I). Scale bar, 100 μm.
