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. 2018 Mar 22;72(3):694–705. doi: 10.1007/s11418-018-1207-9

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© The Author(s) 2018

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.

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Fig. 1 — Junchoto (JCT)-induced CFTR currents in HEK293T cells transiently transfected with CFTR. a Representative records of whole-cell current activation in CFTR- (left) and vector-transfected (right) cells before and after application of 400 μg/mL JCT (filled bars), taken during the application of alternating pulses from 0 to ± 40 mV every 10 s. The asterisks denote times when step pulses were applied. The inset shows a membrane displaying immunoblot of CFTR protein from control (vector-transfected) and CFTR transfected HEK293T cells in the upper lane. Note that the lower band is only detected in CFTR-transfected HEK293T cells. Alpha-tubulin bands with molecular mass 50 kDa were detected at equal levels in the lower lane. b The current response to step pulses from −100 to +100 mV for CFTR (top traces) and the vector (bottom trace). c I–V relationships for the mean JCT-activated current densities for cells expressing CFTR (open circles; n = 6) and vector (filled triangles; n = 6)