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. 2017 Dec 18;14(3):412–424. doi: 10.1007/s12015-017-9790-9

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© The Author(s) 2017, corrected publication January/2018

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.

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Fig. 9 — Haematoxylin and eosin staining for lungs treated with control media (a) and iPSC conditioned media (b). Administration of iPSC-cm to bleomycin-injured rat lungs showed significant attenuation of fibrosis as assessed by semi-quantitative analysis using the Ashcroft score (control media 3.93 ± 0.30 vs iPSC-cm treated 2.4 ± 0.34), healthy controls: (1.74 ± 0.42) (c). In accordance, marked reduction in the soluble collagen content was detected in the lungs of iPSC-cm-treated animals compared with bleomycin animals (57.74 ± 9.3 μg/mg vs. 202 ± 29.57 μg/mg). Collagen content of healthy lung was 10.04 ± 1.49 μg/mg (d)