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March1deficiency is associated with downregulation of IL-10 production. Splenocytes were isolated and cultured for 3 days with 1 mg/mL OVA. Supernatants were collected and assayed for IFN-γ (a), IL-5 (b), and IL-10 (c). ∗ and ∗∗ denote statistically significant. #p < 0.1 (trend). Data are pooled from 3 independent experiments and presented as mean with SEM; n = 6–8/group.
