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. Author manuscript; available in PMC: 2019 Jun 15.
Published in final edited form as: Biol Psychiatry. 2017 Nov 20;83(12):1024–1035. doi: 10.1016/j.biopsych.2017.10.031

Figure 1.

Figure 1

In control rats, daily LgA to cocaine self-administration produced a gradual escalation of cocaine intake (A), reflected by a higher cumulative intake (B), a higher intake during the first h of the final self-administration session (C), and a higher intake during a PR schedule of reinforcement (D), when compared to daily ShA self-administration. Withdrawal from both ShA and LgA to cocaine reduced the number of open arm entries on the EPM (E), without affecting locomotor activity (F). ShA cocaine self-administration reduced CRF immunodensity levels in the PVN (G), but not in the CeA (H). In contrast, LgA cocaine self-administration reduced CRF in the CeA (H), but not the PVN (G). *Significant change (P<0.05) vs ShA or naive, n.s: no significant change. Given their similar total intake of cocaine (see supplementary Figure S4), data of SERT WT and shSCR rats were pooled and each graph shows the mean ± S.E.M. of this combined group of animals. Naive (blue): n=37 (SERT WT: n=13, MRN shSCR: n=9, DRN shSCR: n=15), ShA (blue): n=41 (SERT WT: n=14, MRN shSCR: n=13, DRN shSCR: n=14), LgA (blue): n=37 (SERT WT: n=10, MRN shSCR: n=15, DRN shSCR: n=12).