Skip to main content
. Author manuscript; available in PMC: 2019 Jun 15.
Published in final edited form as: Biol Psychiatry. 2017 Nov 20;83(12):1024–1035. doi: 10.1016/j.biopsych.2017.10.031

Figure 4.

Figure 4

SERT KD in the MRN increased daily cocaine intake (A–B), cumulative cocaine intake (C), intake during the first h of the final self-administration session (D), and intake during a PR schedule of reinforcement (E) in rats exposed to ShA, but not LgA, cocaine self-administration. MRN-specific SERT KD also reduced open arm entries, but not locomotor activity, on the EPM after ShA, but not LgA, to cocaine (F and G). The lack of shSERT2 effects on LgA cocaine intake (B) is accompanied by a lack of effect on CRF immunodensity in the PVN (H) and CeA (I) of LgA rats. In contrast, the shSERT2-induced increase in ShA cocaine intake (A) was accompanied by a reduction of CRF immunodensity in the PVN (H), but not CeA (I), of ShA rats (see Supplementary Figure S8 for representative pictures). In panels C–I, data are normalized to values obtained in shSCR counterparts (see Supplementary Table S6 for absolute values). *Significant change (P<0.05) vs shSCR, n.s: no significant change. ShA: shSCR (blue): n=13, shSERT2 (orange): n=13; LgA: shSCR (blue): n=15, shSERT2 (orange): n=13.