Table 3. Summary of critical organ doses from available dosimetric studies for proton therapy (PT) with or without comparison to intensity-modulated radiotherapy (IMRT) in the literature.
| Critical organ | Parikh et al. (22) | Vogel et al. (23) | Vogel et al. (24) | Present study |
|---|---|---|---|---|
| Mean heart dose (range), Gy | ||||
| PT | 6.0 (N/A) | 9.6 (0.5–33.6) | 9.9 (2.6–33.5) | 15.3 (7.5–25.9) |
| IMRT | 10.4 (N/A) | N/A | 18.2 (6.0–38.8) | 22.8 (15–31.4) |
| Mean esophageal dose (range), Gy | ||||
| PT | 5.4 (N/A) | 9.7 (0.0–46.5) | N/A | 12.3 (1.6–27.4) |
| IMRT | 20.6 (N/A) | N/A | N/A | 27.6 (14.3–36.5) |
| Mean lung dose (range), Gy | ||||
| PT | 4.6 (N/A) | 9.4 (0.1–20.5) | 8.5 (1.1–20.5) | 10.9 (4.9–16.9) |
| IMRT | 8.1 (N/A) | N/A | 11.8 (4.0–23.7) | 16.0 (11.5–21.6) |
| Lung V20 (range), % | ||||
| PT | N/A | 18.0 (0.0–38.0) | 17 (0.0–37.0) | 20.3 (10.1–30.9) |
| IMRT | N/A | N/A | 21 (3.0–56.0) | 27.9 (20.9–42.6) |
N/A, not applicable; PT, proton therapy; IMRT, intensity-modulated radiotherapy.