Table 2.
Results of adjusted mixed multilevel regression analyses of anti-PGL-I, anti-LID-1, and anti-NDO-LID serology overtime in leprosy patients treated with R-MDT and U-MDT.
| Coefficient | SE | z | p > z | 95% Confidence interval | ||
|---|---|---|---|---|---|---|
| Anti-PGL-I | ||||||
| Month | −0.006871 | 0.0007285 | −9.43 | 0 | −0.0082988 | −0.0054431 |
| Group | −0.0035163 | 0.0333417 | −0.11 | 0.916 | −0.0688648 | 0.0618322 |
| _Cons | 0.5085021 | 0.1160942 | 4.38 | 0 | 0.2809617 | 0.7360426 |
| Anti-LID-1 | ||||||
| Month | −0.0051023 | 0.0003361 | −15.18 | 0 | −0.005761 | −0.0044436 |
| Group | −0.0571696 | 0.0719866 | −0.79 | 0.427 | −0.1982608 | 0.0839216 |
| _Cons | 1.618.408 | 0.2525812 | 6.41 | 0 | 1.123.358 | 2.113.458 |
| Anti-NDO-LID | ||||||
| Month | −0.0164264 | 0.0012887 | −12.75 | 0 | −0.0189521 | −0.0139006 |
| Group | 0.0016501 | 0.074866 | 0.02 | 0.982 | −0.1450847 | 0.1483848 |
| _Cons | 1.379.876 | 0.2617582 | 5.27 | 0 | 0.866839 | 1.892.912 |
The mixed effects multilevel regression analyses evaluated the individual results of anti-PGL-I, anti-LID-1, and anti-ND-O-LID serology during follow-up considering the serological result as the independent variable (constant), the dependent variables were time (month) and treatment group (R-MDT and U-MDT) and the group variable was the patient ID. These analyses showed that the difference in serologic decay to all three antigens was dependent upon time only.
PGL-I, phenollic glycolipid-I antigen; R-MDT, regular multidrug therapy; U-MDT, uniform multidrug therapy.