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. 2018 May 14;9:508. doi: 10.3389/fphys.2018.00508

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Copyright © 2018 Martinez-Pinna, Soriano, Tudurí, Nadal and de Castro.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Anthracene-9′-carboxylic acid (9AC) abolishes ADPs without affecting synaptic transmission. (A) Representative recordings of ADPs were evoked after a train of 35 APs in control solution (black traces). ADPs disappeared completely (top panel) or were significantly reduced (low panel) after the addition of 2 mM 9AC (blue traces). Recordings of top panels are from the same cell before and after application of 9AC. The same applies to low panels. APs were evoked with short (5 ms) intracellular current pulses at 35 Hz shown in each recording below the membrane potential. Spikes are truncated at the top. Calibration bars apply to all panels. (B) Representative recording of an excitatory post-synaptic potential (EPSP) elicited with preganglionic stimulus in the refractory period of the AP of one cell in control solution. Addition of the chloride channel blocker 2 mM 9AC does not significantly modify the amplitude of EPSP. Two recordings are overimposed in B, one without stimulation of the preganglionic trunk (black and blue traces for control and 9AC, respectively) and the other with its stimulation and the evoked EPSP (red traces). Calibration bars apply to both panels. APs were evoked with a short (5 ms) intracellular current pulse shown in each recording below the membrane potential. The RMP of the cells is indicated at the beginning of each recording.