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. 2018 May 14;9:508. doi: 10.3389/fphys.2018.00508

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Copyright © 2018 Martinez-Pinna, Soriano, Tudurí, Nadal and de Castro.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Ca²⁺-activated Cl^- current is larger in male than in female mouse SCG neurons. (A) Representative recordings of isolated CaCC after a single AP (left) and after a train of 6 spikes at 40 Hz (right) in an hybrid-clamp protocol in the presence of apamin to block I_K(Ca) (see section “Material and Methods”). APs were evoked with short (5 ms) intracellular current pulses (0.5–1 nA). Recordings from male (black) and female (magenta) are superimposed. (B) Average values of isolated CaCCs after a single AP (left) and after a train of 6 spikes at 40 Hz (right) in males (8 cells; black) and females (8 cells; magenta). Student’s t-test: ^∗P < 0.05; ^∗∗P < 0.01. (C) SCG mRNA expression levels of Ano1 (male n = 9, female n = 8), normalized to that of Hprt. Mann–Whitney test, ^∗∗∗P < 0.0001.