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Excess of rare functional variants in common variable immunodeficiency (CVID) patients.
| Gene | Rare Funct CVID | Syn CVID | Rare Funct Controls | Syn Controls | P-value |
|---|---|---|---|---|---|
| PRKCD | 3 | 4 | 5 | 1693 | 2.36e−06 |
| CLEC16A | 6 | 11 | 8 | 321 | 1.30e−05 |
| DOCK8 | 3 | 11 | 0 | 347 | 4.68e−05 |
| PLCG2 | 4 | 14 | 18 | 1465 | 9.28e−05 |
Rare Funct, number of rare genetic variants; Syn, number of synonymous variants.
